Current Issue : July - September Volume : 2020 Issue Number : 3 Articles : 5 Articles
Visual impairment and blindness affects 285 million people worldwide, resulting in a\nhigh public health burden. This study reports, for the first time, the use of three-dimensional (3D)\nprinting to create orally disintegrating printlets (ODPs) suited for patients with visual impairment.\nPrintlets were designed with Braille and Moon patterns on their surface, enabling patients to identify\nmedications when taken out of their original packaging. Printlets with different shapes were fabricated\nto offer additional information, such as the medication indication or its dosing regimen. Despite the\npresence of the patterns, the printlets retained their original mechanical properties and dissolution\ncharacteristics, wherein all the printlets disintegrated within...................
Chitosan (CHI) and chitosan/poly(2-ethyl-2-oxazoline) (CHI/POZ)-based films were prepared\nby casting from aqueous solutions of polymer blends with different compositions. Ciprofloxacin was\nused as a model drug in these formulations. The weight, thickness, folding endurance and transparency\nof blend films were measured and characterised. All films had a uniform thickness (0.06...................
In order to achieve a controlled release drug delivery system (DDS) for cancer therapy, a pH\nand redox dual-responsive mesoporous silica nanoparticles (MSN)-sulfur (S)-S- chitosan (CS) DDS was\nprepared via an amide reaction of dithiodipropionic acid with amino groups on the surface of MSN\nand amino groups on the surface of CS. Using salicylic acid (SA) as a model drug, SA.....................
Lamivudine (3TC) and zidovudine (AZT) are antiviral agents used to manage HIV/AIDS\ninfection. The compounds require frequent dosing, exhibit unpredictable bioavailability and a side\neffect profile that includes hepato- and haema-toxicity. A novel pseudo one-solvent bottom-up\napproach and Design of Experiments using sodium dodecyl sulphate (SDS) and Alpha-tocopheryl\npolyethylene glycol succinate 1000 (TPGS 1000) to electrosterically stablize the nano co-crystals was\nused to develop, produce and optimize 3TC and AZT nano co-crystals. Equimolar solutions of 3TC\nin surfactant dissolved in de-ionised water and AZT in methanol were rapidly injected into a vessel..................
Cisplatin is one of the most leading potent chemotherapy drugs prescribed for the treatment\nof most solid tumors. However, the induction of toxicities and the development of resistance restricts\nits applications. Efforts are made in the proposed study to control the delivery of cisplatin to tumor\nsites by incorporating it into solid lipid nanoparticle (SLNs) drug carriers. By considering this\nfact, in the current research work, a single-step, one-pot, microwave-assisted technology was used\nto produce cisplatin-loaded SLNs. The shape of the SLNs was observed to be spherical, with a\nuniform size distribution of 74.85 nm, polydispersity index (PDI) of 0.311, and zeta potential of......................
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